The present study was conducted on 24 Wistar rats by administering isoniazid (ISN), rifampicin (RIF), vitamin E and Withania somnifera for 21 days. Whole blood and serum samples were collected on day 21 and were subjected to haematological and biochemical assays. The mean PCV, Hb and TEC values of group II showed a significant reduction in comparison to other groups, while the TLC values of group II showed significant increase in comparison to other groups. The serum AST, ALT and GGT activities were increased significantly in group II. Total cholesterol and triglycerides in toxic group were significantly increased, while the levels of HDL cholesterol and total protein were decreased in comparison to other groups. Enhanced lipid peroxidation in tissues was observed indicating oxidative damage. Vitamin E and Withania somnifera reversed the changes caused by ISN and RIF.
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